μVeNUS microscope

Key Features

Exceptional engineering designed for life science imaging

Modular Design

Flexible configuration to meet diverse research needs.

Multi-Wavelength Support

Compatible with multi-channel fluorescence imaging.

Automated Operation

Intelligent software facilitates efficient experimental workflows.

Precise Optical Alignment

Automatic light-sheet calibration ensures optimal imaging quality.

What Makes SLAM Unique

Scanned Light-Array Microscopy (SLAM) is a next-generation imaging innovation that brings ultra-high-speed, high-resolution volumetric imaging capabilities to standard upright microscope platforms.

Unlike traditional orthogonal, dual-objective light-sheet designs, SLAM introduces tilted light-sheet arrays entering the sample from below at specific angles. This innovation allows SLAM to maintain the key advantages of light-sheet imaging—optical sectioning, low photobleaching, and fast 3D imaging—while remaining fully compatible with conventional sample formats such as slides, culture dishes, multi-well plates, and live models.

How SLAM Works

At the core of SLAM is a specially designed illumination module that replaces the traditional microscope condenser. This module generates multiple thin light sheets, which are diffracted by a high-efficiency transmission grating to enter the sample at an oblique angle. A high-speed galvanometer scanner moves the light-sheet array at extremely high frequencies, achieving millisecond-level volumetric scanning, while a scientific-grade CMOS camera synchronously captures each illuminated slice in parallel.

Advantages of this design:

Ultra-high-speed volumetric imaging (verified >100 volumes/sec)

Extremely low photodamage due to selective plane illumination

High contrast and excellent optical sectioning capability provided by each thin light sheet

Full compatibility with standard sample carriers

Flexible resolution modes ranging from mesoscopic to microscopic

Optional deep learning enhancement for near-isotropic resolution

SLAM brings the speed and performance of frontier light-sheet imaging into daily life science experimental workflows—without the complex optics, high costs, or bulky geometry of traditional systems.

Slanted Light-Sheet Generation

Illumination Geometry: Slanted Light-Sheet Entry from Below the Sample

SLAM introduces a slanted light-sheet illumination path that enters the sample from below through a transmission grating (TG). The illumination objective (IO) generates multiple beams that are diffracted into discrete first-order angles, producing a set of thin, angled light-sheets. These sheets intersect the sample plane obliquely, enabling optical sectioning without requiring a side-mounted or orthogonal objective.

A standard detection objective (DO) collects fluorescence or scattering from above, allowing SLAM to work seamlessly with conventional slides, cover glass, and sample stages. This geometry preserves compatibility with existing workflows while delivering light-sheet performance at high speed.

Parallel Plane Acquisition & 3D Reconstruction

Parallel Acquisition: Multiple light sheets captured simultaneously in each frame

SLAM acquires 3D data through simultaneous illumination by multiple oblique light sheets. At each step of the lateral scan, multiple spatially separated bright bands appear in the raw camera frame, each corresponding to a light-sheet plane (e.g., LS1, LS2, LS3...), representing information from different depth layers.

During reconstruction, these planar signals are precisely mapped back to their corresponding 3D positions. Parallel acquisition significantly reduces scanning steps, enabling imaging speeds exceeding 100 volumes per second.

Key Steps:

Each frame contains multi-layer light-sheet information:Multiple bands in the raw frame represent light-sheet slices at different depths.

Stepwise Acquisition:As the light-sheet array moves, new frames fill in missing depth regions.

Computational Mapping:Signals from each oblique light sheet are reassigned to their true axial positions (z).

Final Output:Continuous, high-temporal-resolution 3D data volumes.

Why Choose μVeNUS?

Experience the superior advantages of frontier light-sheet microscopy technology.

Superior imaging quality with simultaneously achieved low phototoxicity

High-speed volumetric imaging to capture rapid dynamic biological processes

Highly versatile platform adaptable to various sample types

User-friendly interface with automated features to enhance efficiency

Comprehensive support and training system

Open architecture facilitating customized application development

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Technical Specifications

Detailed parameters of the standard system are listed below.

For customization and upgrades, please contact us.

Optical Path Type	Horizontal Optical Path
Excitation Objective	5×/0.16; 10×/0.3
Detection Objective	5×/0.16; 10×/0.3
Imaging Range	1.37 mm × 1.37 mm
Imaging Speed	1 ± 0.25 mm/min
Light-Sheet Calibration	Automatic Calibration
Sample Stage	3D Motorized Sample Stage
Sample Mounting Method	Dedicated Sample Chamber
Laser Source	488 nm, 561 nm, 647 nm
Clearing Requirement	Recommended Refractive Index ≈ 1.46

System Customization

Tailor μVeNUS to perfectly fit your research needs

Modular Components

Choose from various detection objectives, cameras, and laser modules to create your ideal system configuration

Optical Configuration

Customize wavelength combinations, filter sets, and illumination modes to match specific experimental requirements

Functional Expansion Modules

Add-on options include environmental control, multi-position stages, automated sample handling modules, and more

Software Customization

Customize acquisition protocols and analysis workflows, seamlessly integrating into existing laboratory systems

Need the most suitable system configuration for your research? Our expert team is ready to assist you.

Consult Our Technical Experts

Resolution	2048 × 2048
Pixel Size	6.5 µm × 6.5 µm
Max Frame Rate	100 fps @ 2048 × 2048
Cooling Method	Air Cooled

Data Acquisition	Integrated Control Software
Data Pre-processing	Real-time Processing Pipeline
Large Data Stitching	Automatic Multi-tile Stitching

Slanted Light-Sheet Microscope